Oleandrin is a molecule that is extracted from [the] Nerium oleander plant and is specifically formulated for oral administration.
Phoenix Biotechnology:
Summary of Research & Safety
Imagine you discovered a new drug for treating COVID-19, but the Food and Drug Administration (FDA) is blocking you. Your new drug has inhibited the action of COVID-19 in monkey liver cells. It has already tested safe as a cancer treatment in humans, but the FDA insists it’s unsafe as a COVID-19 treatment. So what do you do?
Through political contacts you are able to meet with President Donald Trump, who sits down and listens patiently. The President then calls in the head of the FDA and says: “Get this done by Friday.” But five weeks later the FDA has done nothing. Not a thing.
And so the case must be brought before the American people. But here stands another obstacle. The mainstream media, rather than examining the new drug dispassionately, dismisses its importance. Mainstream journalists aren’t remotely curious regarding the drug’s promising antiviral properties.
The idea is to save lives and return the economy to normal functioning, right? But that isn’t what the leftists in the media, government and business want. They want to use the pandemic to justify what is called “the Great Reset,” described as a “restructuring” of the global economy toward socialism.
Clearly, for these folks, the pandemic is not simply a medical crisis. It signifies a revolutionary opportunity; that is, a pretext to overthrow capitalism. A cure, therefore, would be inopportune. It would stop the revolution in its tracks, returning life to normal.
The left does not want a cure. They therefore opposes any drug, any treatment, any measure which would return life to normal; for the pandemic occasions a tightening of controls in favor of “scientific socialism.” According to the founder and executive chairman of the World Economic Forum, Klaus Schwab, “Every country, from the United States to China, must participate, and every industry, from oil and gas to tech, must be transformed.” Fundamental change is urgently needed, say the socialists who support this “new initiative for a sustainable post-pandemic world.” COVID-19, they claim, “has exposed many underlying structural and institutional inequalities.”
This Marxist verbiage is used to advocate a global administrative revolution. The Marxists in government combine with activists in the street, following Stalin’s classic model of “pressure from above, pressure from below.” At the same time street activists are demanding an end to “systemic racism,” business and political leaders at the World Economic Forum want to address inequalities made manifest by the virus. They want to “put people first.” What does that mean? — the World Economic Forum tells us, “Governments, business and the philanthropic sector must lead in creating a fairer world.”
Meanwhile, keeping the lockdowns going while thousands die, the left’s bureaucratic co-religionists block a possible cure. This shows us what socialists are all about. Their supposed concern for people is a lie. Their only real concern is to extend their power.
A cure for the virus is in prospect and the left blocks it, the media blocks it, the bureaucracy blocks it. President Trump orders the FDA to allow testing. Five weeks later, after tens of thousands of lost lives, the left does nothing but blame Trump. Their slogans are Marxist. They rely on words like “fairness” and “equality” while engaged in a massive power grab.
Is oleandrin a cure for COVID-19? What would be the harm in finding out? The FDA should step aside and allow the new drug to be tested. Wouldn’t that be the scientific thing to do — rather than belittling oleandrin as beneath notice?
Oleandrin FAQ
1. Is oleandrin safe?
Yes. Oleandrin is a unique compound of an extract of the common Nerium oleander plant and is the main ingredient in a dietary supplement proposed by Phoenix Biotechnology. Similar plant extracts of the Neriumoleander plant have been used in Phase I and Phase II clinical trials in cancer patients that successfully established the pharmacokinetics (an effective and safe dosage rate) of oleandrin.
2. What is the difference between the Oleander plant and oleandrin?
The Nerium oleander plant is poisonous if the leaves andstems are ingested by animals and humans. That said, there are many isolated plant molecules that are important and extremely effective when separated from the plant itself. For instance, a molecule in the Periwinkle flower provides an important treatment for cancer. The molecule, Taxol, derived from the bark of the Pacific yew tree, is the most well known natural-source cancer drug in the United States. oleandrin belongs to the class of compounds known as cardiac glycosides related to existing digitalis-like drugs,which are effective in guarding against congestive heart failure and have been found to have strong anti-viral properties as well.
The safe and proper isolation of oleandrin from the Neriumoleander plant requires specialized knowledge and extraction facilities.
3. What are the side effects?
Our proposed oleandrin product is 1/16th the potency of the highest dose achieved in the Phase I/II cancer trials before any side effects were observed. No side effects have been observed at this dosing level.
4. How many people have been given oleandrin?
Between the phase I first-in-human dose finding, phase II cancer trial, and extensive trials with other entities, in excess of 1,000 patients have safely been treated with oleandrin.
5. How do I take it?
For this proposed product that contains oleandrin, the suggested dose is 0.5ml under the tongue for one minute, four times daily. The product enters the body quickly and efficiently through sublingual absorption.
6. How long do I take it for?
The proposed product vial contains approximately 7 days of therapy. Some patients only require one vial while others may require more, depending on their situation.
7. How does oleandrin work?
Oleandrin has been shown to have strong antiviral activity against “enveloped” viruses such as Ebola, Marburg, HIV and HTLV-1. It was therefore tested for antiviral activity against SARS-CoV-2 (Covid-19), which is also an enveloped virus. These studies were performed at the World Reference Center for Emerging Viruses and Arboviruses at the University of Texas Medical Branch (UTMB), in Galveston over this past spring and summer. UTMB has conducted tests on some 53,000 potential COVID-19 therapeutics, by their count. For our drug, an average 20,000-fold reduction in COVID-19 infectivity during 24 hours was observed. This increased to nearly 100,000-fold by 48 hours.
8. Does Oleandrin work prophylactically?
A recent study in Vero cells at UTMB found prophylactic oleandrin administration at concentrations down to 0.05 μg/ml exhibited potent antiviral activity against SARS-CoV-2 (Covid-19).
9. What is it combined with to create the product oil?
Like CBD oil, our proposed oleander product is combined with Medium Chain Triglyceride (MCT) oil and natural flavoring. There are no artificial additives.
10. What about allergies to Orange, Coconut, or oleander?
It has been shown in several respected journals that coconut derived MCT oil should not cause allergies in those that have allergies to tree nuts. Coconut allergy itself is extremely rare. The oleandrin product is also flavored with natural blood orange flavor. Citrus allergies are also exceedingly rare; however, they do occur. The blood orange flavor is all natural and derived from the blood orange. If someone is concerned with a potential allergy to this product, they should be cautioned and if they do wish to try the product, they should do so under a physician’s supervision as a food challenge.
Notes and Links
“Introducing the ‘Great Reset,’ world leaders’ radical plan to transform the economy” — https://www.google.com/amp/s/thehill.com/opinion/energy-environment/504499-introducing-the-great-reset-world-leaders-radical-plan-to%3famp
“How the world can ‘reset’ itself after COVID-19 – according to these experts” — https://www.weforum.org/agenda/2020/06/covid19-great-reset-gita-gopinath-jennifer-morgan-sharan-burrow-climate/
“The Great Reset after COVID-19 must put people first” — https://www.weforum.org/agenda/2020/06/covid19-reset-people-first-inequality/
[In the following hit-piece, published by the Trump-hating Washington Post, Oleandrin is subtly debunked as just another toxic panacea, like Hydroxychloroquine — an anti-malaria drug that has become a leftist media byword for dangerous snake oil.] “The lost days of summer: How Trump fell short in containing the virus” — https://www.washingtonpost.com/politics/trump-struggled-summer-coronavirus/2020/08/08/e12ceace-d80a-11ea-aff6-220dd3a14741_story.html
Summary of non-clinical studies using Nerium oleander extracts (oleandrin)
Study type | Dose | Comparison to 4 Servings/day oleandrin 6.25 ug/serving x 4 servings/day = 25 ug/day | Cell type or species | Reference |
Anti-viral activity | 10, 50, and 100 ug oleandrin | Greater than one serving | Human PMBCs | Hutchison et al. (2019) https://pubmed.ncbi.nlm.nih.gov/31824586/ |
100 ng/mL of oleandrin | Less than one serving | Human PMBCs | Singh et al. (2013) https://www.sciencedirect.com/science/article/abs/pii/S0367326X12002936?via%3Dihub | |
Conc. Range 0.005 to 1.0 ug/mL for 24 and 48 hrs | Less than one serving | Vero (African Green monkey kidney) cells in culture | Newman (2020) https://www.biorxiv.org/content/10.1101/2020.07.15.203489v1.full | |
Tumor cell cytotoxicity | 1.0 ng/ml, 10.0 ng/ml, 0.1 ug/mL and 1.0 ug/mL for 24 hrs | Less than one serving | Human prostate, mouse and canine melanoma cells in culture | Pathak et al. (2000) https://pubmed.ncbi.nlm.nih.gov/11001386/ |
10 nM and 33 nM exposure ranging from 1-120 hrs | Human melanoma cells in culture | Newman et al. (2006) https://www.researchgate.net/profile/Edward_Felix/publication/7249455_Oleandrin-mediated_oxidative_stress_in_human_melanoma_cells/links/00b49526ec31df0fc6000000/Oleandrin-mediated-oxidative-stress-in-human-melanoma-cells.pdf | ||
Conc. Range 2-1000 nM for 48 hrs | Human and mouse melanoma cells in culture | Lin et al. (2008) https://pubmed.ncbi.nlm.nih.gov/19066128/ | ||
Conc. Range 2.5-160 ng/mL for 48 hrs | Less than one serving | Human lung cancer cell line in culture | Frese et al. (2006) https://pubmed.ncbi.nlm.nih.gov/16740726/ | |
0.05 g/mL for 24 hrs | Less than one serving | Human prostate cancer cells in culture | Nasu et al. (2002) https://pubmed.ncbi.nlm.nih.gov/12169388/ | |
50 nM for 24 and 48 hrs | Human prostate cancer cells in culture | McConkey et al. (2000) https://journals.lww.com/anti-cancerdrugs/Citation/2001/08000/Oleander_extract_induces_cell_death_in_human_but.13.aspx | ||
0.05 and 0.1 ng/mL for up to 72 hrs | Less than one serving | Human prostate cancer cells in culture | Smith et al. (2001) https://pubmed.ncbi.nlm.nih.gov/11448457/ | |
Conc. Range 0.01– 10 g/mL for 1 hr | Range less than to greater than one serving | Human and mouse cancer cells in culture | Manna et al. (2000) https://pubmed.ncbi.nlm.nih.gov/10919658/ | |
Conc. Range 0.2 -1.0 g/mL for 4 or 6 hrs | Less than one serving | Human, monkey and mouse cells in culture | Sreenivasan et al. (2003) https://pubmed.ncbi.nlm.nih.gov/14609747/ | |
5, 10, and 25 nM (approx. 0.1, 0.2, and 0.5 nM oleandrin content) | Less than one serving | Human pancreatic tumor cells in culture | Clinical Trial IND 73624 | |
10, 20, and 40 mg/kg (approx. 0.2, 0.4, 0.8 mg/kg oleandrin content) | Greater than one serving | Human pancreatic cancer Panc-1 and Capan-II cells in Mouse | Pan et al. (2015) https://pubmed.ncbi.nlm.nih.gov/25476893/ | |
Pharmacokinetic studies | i.v. dose (40 ug/kg) or oral dose (80 ug/kg) oleandrin | Less than one serving | Mouse | Ni et al. (2002 https://pubmed.ncbi.nlm.nih.gov/12416031/ ) |
Pharm/tox | 116 mg/kg/day for 7 days and 21 days, orally (approx. 2.32 mg/kg/day oleandrin content) | Less than one serving | Rat | Clinical Trial IND 73624 https://clinicaltrials.gov/ct2/show/NCT04486144?term=oleander&draw=2&rank=1 |
0.1, 0.3, or 1.0/0.6 mg/kg for 28 days (approx. 0.002, 0.006, or 0.02/0.012 mg/kg oleandrin content) | Greater than one serving | Dog | Clinical Trial IND 73624 https://clinicaltrials.gov/ct2/show/NCT04486144?term=oleander&draw=2&rank=1 | |
Dose-range finding | 19, 39, 77, and 116 mg/kg as oral gavage for 7 days (approx. 0.38, 0.78, 1.54, 2.32 mg/kg oleandrin content) | Less than one serving | Rat | Clinical Trial IND 73624 https://clinicaltrials.gov/ct2/show/NCT04486144?term=oleander&draw=2&rank=1 |
Multiple-dose toxicity | 19, 58, and 116 mg/kg as oral gavage for 14 days (approx. 0.38, 1.16, 2.32 mg/kg oleandrin content) | Less than one serving | ||
Dose-range finding | 5, 10, and 20 mg/kg for 3-day oral dose escalation (approx. 0.1, 0.2, 0.4 mg/kg oleandrin content) | Greater than one serving | Dog | Clinical Trial IND 73624 https://clinicaltrials.gov/ct2/show/NCT04486144?term=oleander&draw=2&rank=1 |
Summary of clinical studies using Nerium oleander extracts (oleandrin)
Study type | Comparison to 4 Servings/day of NDI oleandrin 6.25 ug/serving x 4 servings/day = 25 ug/day | ROA | Disease | Reference |
Ph1 trial of Anvirzel™ | Not an oral product | Injection | Advanced malignancies | Mekhail et al. (2006) https://pubmed.ncbi.nlm.nih.gov/16763787/ |
Ph1 trial of PBI-05204 | equal to 4 servings/day | Oral | Advanced malignancies | Hong et al. (2014) https://pubmed.ncbi.nlm.nih.gov/24919855/ |
Ph2 trial of PBI-05204 | 10X greater than 4 servings/day | Oral | Metastatic pancreatic cancer | Roth et al. (2020) https://pubmed.ncbi.nlm.nih.gov/32452588/ Pan et al (2015) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387257/ |
“You never want a serious crisis to go to waste. And what I mean by that is an opportunity to do things that you think you could not do before.” ― Rahm Emanuel
As you said, Jeff, they believe it’s a revolutionary opportunity. 🙁
Praying in OK
What I found curious is the fact that in October of 2019 Hydroxychloroquine was reclassified as a dangerous drug in France and removed from shelves in mid January 2020. Before this action, Hydroxychloroquine had been available for sale like asprin. For over 50 years if was considered an extremely safe drug, cheap, and readily available. The timing is extraordinary and it seems to me that they knew the pandemic was coming and wanted to eliminate potential treatments. There are powers that do not want treatments or cures.
The Russians were busy buying it in large quantities.
If you’re talking Russians Buying in Oct 2019 I’d like to a link to that statement.
If you were just being sarcastic then you should say so —
I didn’t say anything about October. The Russians embraced the drug in April. https://www.themoscowtimes.com/2020/04/17/russia-approves-unproven-malaria-drug-to-treat-coronavirus-a70025 — you could have easily found this yourself with a simple google search. The news on this was all over the Internet last spring.
A+ article “as usual”. Extremely talented writer and researcher with a firm grasp on the English language, superior writing style, and over the top knowledge of geopolitics
Great post, as usual. You’re gonna get me banned on Social Media, I keep posting your articles. That’s ok, this information needs to get out. I have been following a vitamin guy, for years, he’s gotten into trouble posting Covid stuff. Check out “doctor yourself dot com” and look for the Covid info. There are cures, and prevention, available, but as you say, it does not fit the agenda.
Thank you for your service to the true reality of our times.
Thanks Vincent. Good information on a natural protocol to improve immunity.
It’s a strange thing to get banned for relating information about new treatments. What have we come to?
I seek hope and vision for a brighter future. However, Western Civilization has sown to the wind, and we have forgotten history. As you have so deftly pointed out our enemies are within and without our gates. I fear that my children will never know the greatness of America, the America that we have known and loved.
Thank you for your interaction.
To some extent, at least since the early 1900s, there has always been some interference with the production and distribution of drugs and herbal medicines. It has become much worse over the past 25+ years unfortunately.
Too much money to be made with lesser quality treatments, then to put products on the market that could cure or at least bring down the mortality levels, if allowed to be put on the markets. Very sad situation.
So many of our drugs are toxic already, the process seems arbitrary at best, capricious at worst.
If the FDA is not doing as the President directed can he fire people at this point?
Federal employees have rights!
President Reagan fired the PATCO Air Traffic Controllers which were under the FAA I believe back in 1981. Maybe technically they were not Federal employees under a Union.
It would seem Trump could do the same.
Good point
This treatment, as with hydroxychloroquine, are disregarded and ignored by Big Pharma, the government, and the media (who make big $ off Big Pharma) because if there is a successful treatment for Covid then they will be unable to force the very lucrative vaccines on us. Think about it – 7.8 billion people taking probably 2 doses of a vaccine every year forever vs. sick people doing a treatment for a week or two. Staggering profits to be made.
There are many cures for viruses—mostly very cheap. Garlic oil—lactoferrin—artemisinin—three that get little mention. These are stand alone cures. No point in using lactoferrin and artemisinin together as they both focus differently on what a virus must have for replication—IRON—same as tumors! Lactoferrin binds to free iron and starves the pathogen. Artemisinin in the presence of high iron concentrations kills the offending entity by free radical damage. Garlic has allicin/sulphur, toxic to invading pathogens. The entire cancer/heart disease/virus industries could be reduced by 95% in size if people would use these cheap natural substances.
Is Oleandrin available at a health food store?